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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cfed1cb57e2a376bc3f7ce365b9fa55d220080e516a006900d88cafcc8d55e33' 
  AND token = 'yURZhG2s6Z1xeFBSr83IunDOoT8LfkEyCVgp+IX5afQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}