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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8b25c3b198b1e1e2d8421052218bf353ecb06025342dae3013ed961225384c66' 
  AND token = 'APDNC1LE3a38Ak+kNpiScfLTUzZAWIwRfHhoS7mZ4J0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}