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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '181c6e0300db7cf73ca8bf81afb96393006fd2e2a5fff676054abcd9e7b4d2da' 
  AND token = 'rG5ga2DfujzebFAUSFpKdF8nUDLsHkeiH7PveSYQ4HQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}