SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5ed79c641b4c1f4eacaeead6625cdfb2564fa60dba04128f87de56ddcbd86483' 
  AND token = 'mP9+KeHEhtwgFJGx9aAwUSu8vVM1DjYt42+K2Kxf/sE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}