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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '727ddcac7f28dac849fd2c77fb2a2d3f2355ed7ad29c5202d37c73caac5cda2c' 
  AND token = '3fTjCpaSyUciSeeT5hew4NL5YOTZaTWDTqTpUYYkUC4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}