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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0d5d2f27a6c11287a73c7ca4874f9c11df83858fd20c5d32e368afaade2391b0' 
  AND token = 'ZFQWbGyv19AAV1QBO+mE8YeQvoMjsdmzfHuqtf6Wz2k=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}