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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd67e4cd0a83d9829067b19202140d272c811daf6b0e2ac0111bfcef9b33aaedc' 
  AND token = 'VZqYSL2/LRCLjJWW345P7cmrRSNKIDc/Ivl/GU3Zrz4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}