SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4073c28e09d5f3f6722b1a989b57b462cab486034a5dce035484a6a2123160d8' 
  AND token = 'Iuvr+9VzdIilqeeei+3xFmdd8WL+qC6iUlw04Kb3Q8M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}