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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4138043bde47da5b0a5a9dbe4685a9b3c318c9d9b475b32d634590494aaa4298' 
  AND token = '3RQY7Z5MGV9N+tUtVrPf4EhYxCgAsXTjwbL9Zvb/ubQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}