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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '278f0b8cda05e9f1ad3c18cadeeda7a38928048b87a018242f887ec480d19059' 
  AND token = 'oE9Zkw1NqP4/Kn3FbLvQE8oECkxu8G4mXYxTd4h8WxE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}