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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8006178b73567520d9fedfcb3da7fa8b18d36d41945018d75e50d9d467c41f4c' 
  AND token = '/Z0wnm17IVK4j2VzPrfrUt6jZZnsKasvOAV7zrcxkE0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}