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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '066f45c3c599233c0f6b57d72f2d89a762cb20bf4abde7f849f2aac46e19b1a6' 
  AND token = 'ErmjoJ+JNxMmgFbfCUUgmJAcbOKO9F4oZZmLEmY0w78=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}