SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22b13ee8d931484528ab69804a2e1dbecc7f4d993710601adf735db2252639b3' 
  AND token = '+rEsyZRfktk2mSWYzxI5w0vtDe0h58rFIQRViGkdKMU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}