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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '414448533f57c1c2c3aedd28d33843e241960981559cc38db2330b6238a80980' 
  AND token = 'ME2FNGLfGzxHxjt2vHlff1eq5gXgqEs6VFiaOWBV0/0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}