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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd75cd9a06f5e268d9f6f020480e9e568ca1d4c33115609febf2519da874b681c' 
  AND token = 'u5T62JTgGI2Cf/Fm/ltmsRTgs9nC0f6SBJbFZOM4bIE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}