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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '454b4bdc25781a98ea65eb234061f2f0ef90d781e70bcd1a4959ce486e76abc1' 
  AND token = '+CFxyse7DSlGSR4JIS86/WgeVXNzIhctNXOpuGPNUMY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00058

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}