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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'cfb3a79f38fa7ab25198508e1336b8b26ca9c21007bf1bb8c60003dc5da7c807' 
  AND token = 'do7lU8LiiOH0uUQNxL1hzPLSkS+4WP+gHIRLWSTH1wY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00058

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}