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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '222184914da968b51eb067cb743165dc9dac1784b80c46422e933491a6783e29' 
  AND token = '4neY1rySj35pkGAr920J+OHuqxPZpOuovU+UKAQlq2U=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}