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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1822f4d5b8cacf781ad7384eeb3498f34a1e314b24194b07275dc45d2727ab75' 
  AND token = 'QO1IuBIfpBdgwjJIW/rxb+p6zKiRi0AOWE57pVJtLJM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}