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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6413d7d2126ec7be93131e391110a8e3f9df19ede48ab10c64d706bfedffada5' 
  AND token = 'BW1kXSs3/sIXMXKIbW+pRF7UtOGTbg0O2EgADIw1Cl0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00035

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}