SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6c78ddf300ab57024411942dc1716934808e982001e80dd2b2a95c2c629d58d5' 
  AND token = 'NYKU7fmbj+tfm4/BWeG4pteOlBNqo4Rd0S1KwEBUq7A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}