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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '61d166fac07ced819d4ca078c0dccd333452f0e4134e07ce74f4d99afc8bd388' 
  AND token = 'yq8G2r9bA+npCLs0WlMJXo2LiIHKWCT5nWLRFPWxPIM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}