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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0001204ead11ad1c1cbd7891c5349110537e999ffb9917208c551c916702d264' 
  AND token = 'SQa2iiE309e/x5GV7sdpGDJjZkzkwlQ0I2TvGhzWRsE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}