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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e290483cb96de003e49f2fcf8cf1d61f03f545d1bb46493b3f93545bde5809ab' 
  AND token = 'ro9sF7VrhB8O+JX6wQeiHiiXvkTdgMB4x6+PY3H5bSM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}