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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1b8cfc40a9e8f3221f082e1c0dd1524e95521ce71f79daaa65af3cfb742c8aa5' 
  AND token = '0wH/XAS7OOzg3L4SiGDapPpTdTnPpTtRLwAPSIWhvIo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}