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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e18f33227a1f043b05347efb0e11bacdcdff0aac40db272da3f8b402a89d5c55' 
  AND token = '5Pfhow3kXJfzFZ9tk0CjB1xy+b8kOMn/FmXDfkbQbeE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}