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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '455278a3101479d5978b0cc84a0db8648b0217dfc6f83c166003e8d1cc24f2af' 
  AND token = 'Ef7FIpFvZsoQEfzlDNHqcOL4c6CR7MBFbjCU6DqyQ2M=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}