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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6456d2ae35a0cadbc6bd9673825aed744cd7693d94379fd891c2d1255e1f3cd6' 
  AND token = 'wQ/e7uGRxw4sDkI9UJxNx5cVKJ9b7Dbt9nX3NeToDmY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}