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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '1095ab7f8862fd1c51b1b39c41f37af257bf68f53b1526830695b56f6a170bf4' 
  AND token = 'UfUD+XOSJ6PDfy8oSrdIdY7TqshJhnTrkRKOwS22mjI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}