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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '16ebc655907e5d20fe3365e3e87f6f416cbfbc6542fc24b82a898435f9741328' 
  AND token = 'H+68v7UAVQlE7fHSNbNCu6gmRoc0b4f7tjoadwSlmmQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}