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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6751bd0b0cc594414d225d2511efba2a4a23e82ca239e847014087b7f1ce5e5f' 
  AND token = 'eBsKs0ItnGS/44V5wa2QuRY8f9u0lmWT9fB3ZcxXIrU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00014

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}