SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78be671e78ddcff89ef729f3b7e965c8d562ab114c11026c2f53e6f69b927e3a' 
  AND token = 'AR55rW22XiJL7sPsoKu2UlSQbvo3y2/ZcwoRob+9PE4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}