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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b424b82d88d2360b01b01ce363888cd48700fbd4e2816a45466a4daf2dc2edc9' 
  AND token = '+AGDY8+ydy9oAfc2OmctRCcV6E3DLXfAKBRhUvr2Ybs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00031

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}