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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '15a6f4e8fdcbcd3172e89d814de78c2f687bcac21f4b9cab1817edced446ca66' 
  AND token = 'RI5lN5/5N14xkQk3JOKLqvpUTq56kjJU1cZ7MzVPcqw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}