SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'c229a058429ac3c040c3836b3d47291987d5be0064a58279059941c09a43e916' 
  AND token = '49AIHqos2RqgMQs1WUScFtDwXet/5sjYlEm3VGV23cc=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00022

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}