SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '022c503c0165c0dff4868e3053795b7d9edc5d883261898b25f209e12ae4a84e' 
  AND token = 'zTBTktk+MZ6maKwMRX6XEwsH5gNNkrYo1kwW53yOGYk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}