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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2b1e1d5d9679e1718b76d88e8256691726da482a9ef270eab9c509ba573d0e54' 
  AND token = 'z71Vxe+MzQ+mvPodwtwdwSrx3jq5ApOo8fcATFT9wp0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}