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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'dd12145054aba285fb3dc07ccfec5f621a37a6a1b592e62fc1cb4bd4f44a4169' 
  AND token = 'sNbSit/JEDkjL9u8/gI9gXXH828bHZrqf35vk4hwb2A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}