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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '43d506963a0a469593d367f84da9d2c9fb9fa129da9281df0e1a53838aa86ff6' 
  AND token = 'MSw1R/+Nai4JOIB/gQttdpoNxdAK7rtQLb1XrtAJlyw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}