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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '42d4267f1314cdf62307067bd7fc38dd98f47c6106c4f77bdaf4f6d9c2381087' 
  AND token = 'VlC8TD8I4zUj1CVgiL5LAMQNJIFGeePr6OMuFfv2W3Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}