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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2e48cecdbfeb2aea4f448d98fd718b5359a350f5c87c08b75c66ffebd5e88c0c' 
  AND token = 'jtLTAk6HlKs01amlVCmPnGy3oeR3UwHm9XB/SCc/eHw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00024

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}