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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'fd8ac8cd421af52c3fe1916ff43b6a5a73081ff0a970642e5d09651355265a7f' 
  AND token = 'jQpZC4WahuTCRqv0KaDWz2k9r9E0XSPE5RXEnsVAXXY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}