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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '52ff2a1341d7fa73cca94816767c5da50e4f65b7025e407aa14dd65078fdb449' 
  AND token = 'a/BmdM0fJq54kCRjjwRFY/00RzhJ/b9HKs+4A3o+WRk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}