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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '00a501ec3d965323d1ec528bd4304aa171d6198701cc699e89a5292c7e41e91c' 
  AND token = 'v21LWgoQVRJqBV/c4bLPNJoAjtwZcj8vr0Q1RI5AhwI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}