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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '22c41960301524e264af03dab97ec4e7fd1724363245435e069a4394114b567d' 
  AND token = 'ZJpqsKb79ekZ8OhA7xddcXtHJjh25rZs6m2zNtDImws=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}