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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4d4424cb29d30bca9748e7597e898dd0a0d0db4182eaec37b174db3daff25816' 
  AND token = 'BWy7SJfM6Krxu0Byg2UYVr6A9gEEjOsjcpCzEYXlIlA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}