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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a81026a1de15d55a92eddf14abb1451c60345295a9957c02e5d71f33291b2e4c' 
  AND token = 'UBeLfXCzgd/jBQNM/gdVH+yAw7vntmF4RcB40sTliRI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00027

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}