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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a21a49dead07396f8d52f52c08090f580d6ec636424d737d42eea10e9c5c2707' 
  AND token = '0RV0V3+nc94mTItGH2aGGHuFdeWOt97l8V6Mb+1l4Sw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00034

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}