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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '53eee276ffe31cc02d8ff2b6f4b46cca543b5eae6874966b8bb18d398312b0f4' 
  AND token = 'Us0Nd/AOuxm1PB3b4IfT/AUY5+dZ84MOoLfNC+TrWAs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}