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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '427b75d0cb01e0658cbb8fcd452e8d24dd23e9511cdf79a41ed10173b8e37d21' 
  AND token = 'O5iE2PWwuRWpGnc3yRzxsC0sRgvtGSlQt4jJ/V22xNs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}